trichloroethylene health effects

14. Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. TCE is carcinogenic to humans by all routes of exposure. An increased risk of developing autoimmune diseases is one of the most consistently reported adverse health effects of TCE . A recent analysis of available 0.2.1.1 ACUTE EXPOSURE. Many types of cardiac arrhythmias can occur and are exacerbated by Environ Health Perspect 117:696–702. 1995. HOW TRICHLOROETHYLENE ENTERS AND AFFECTS YOUR BODY TESTS FOR EXPOSURE AND MEDICAL EFFECTS LEGAL EXPOSURE LIMITS REDUCING YOUR EXPOSURE Health Hazard Summary: Trichloroethylene mainly affects the central nervous system (the brain), causing headache, nausea, dizziness, clumsiness, drowsiness, and other effects like those of being drunk. Sacramento, California. Mundt KA, Birk T, Burch MT. Public health goal for tetrachloroethylene in drinking water. While trichloroethylene (TCE) is not found naturally, it can contaminate water sources and be ingested. When inhaled, trichloroethylene can cause headaches, dizziness, poor coordination, and potentially unconsciousness (similar effects as intoxication). 15:445-452. 10. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 97: 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Studies have shown that simultaneous alcohol consumption and trichloroethylene inhalation increases the toxicity of trichloroethylene in humans. The health effects of trichloroethylene depend on how much trichloroethylene you are exposed to and the length of that exposure. Bofetta P, Matisane L, Mundt KA, Dell LD. As a solvent or as a component of solvent blends trichloroethylene is used with adhesives, lubricants, paints, varnishes, paint strippers, pesticides, and cold metal cleaners. When you are exposed (during pregnancy, in infancy, etc), How you are exposed (breathing, drinking), and. Reproductive Health Effects: A number of studies have suggested a linkage between TCE exposure and birth defects. Health effects with sufficient evidence for causation for TCE. 19. Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. Environ Res 93:248-258. 2013. 20. Therefore, not everyone who is exposed to trichloroethylene (TCE), tetrachloroethylene (PCE), benzene, or vinyl chloride exposure will develop a health problem. Boston, Massachusetts: Massachusetts Department of Public Health. 21. A) GENERAL - Trichloroethylene (TCE) is toxic by ingestion, inhalation or dermal exposure. This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Conclusions cannot be drawn from the limited studies available. 11. Inadequately protected workers can also inhale TCE fumes when working with products containing this toxic chemical. Higher concentrations result in tachypnea. Int Arch Occup Environ Health. Khan HA. Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. 5. Listed below are the health effects where the evidence is sufficient to conclude that a causal relationship is at least as likely as not, but not sufficient to conclude that a causal relationship exists (“equipoise and above”) in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. 18. Vernot EH, MacEwen JD, Haun CC, Kinkead EK [1977]. Research Triangle Park, NC: US Department of Health and Human Services; 2016. Its symptoms are similar to those of alcohol intoxication, beginning with headache, dizziness, and confusion and progressing with increasing exposure to unconsciousness. These effects may be mediated by trichloroethylene acting as a positive allosteric modulator of inhibitory GABAA and glycine receptors. National Toxicology Program (NTP). You may also call your local health department if you have questions or concerns. Exposure to TCE can result in a number of health problems, including respiratory difficulties, liver damage, and even death. 2. Environ Health Perspect 111(2):167-73. Pesticide and Environmental Toxicology Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Public drinking water contamination and birth outcomes. Carcinogenicity of 1,3-butadiene, ethylene oxide, vinyl chloride, vinyl fluoride, and vinyl bromide. 2000. Scand J Work Environ Health. Some evidence suggests that it may be associated with an increased risks of non-Hodgkin lymphoma and, possibly, liver cancer . Arch Environ Health 18(6):894-900. 2007. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. JAMA 281(12): 1106-09. 14th edition. In other words, equipoise and above means that there is enough research to support a link between the health effect and the exposure, but there is not enough research to definitively conclude that exposure causes the health effect. Arch Environ Health 55:188–194. Acquisition of additional data in the following areas would enable a more complete evaluation of the potential effects to the health of the general population in Canada. Trichloroethylene and cancer: epidemiologic evidence. Listed below are the health effects where there is sufficient evidence for causation in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. Single (acute) or short-term exposure can potentially affect the developing fetus. CNS effects; decreased appetite; gastrointestinal irritation; headaches; mucous membrane; skin irritation; Hepatotoxicity has been associated primarily with TCE inhalation and ingestion of very large amounts. The chlorinated hydrocarbon trichloroethylene (TCE) is used extensively in industry as an anesthetic and solvent, thus, this chemical has caused various harmful effects in human beings. Lyon, France 2008. 4. Environ Health Perspect 107(4):265-71. Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (Europe). IRIS assessment development process. Report on carcinogens. Gist GL(1), Burg JR. 1999. Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. Environ Health Perspect 108(S2):161-176. What your personal traits and habits are. 76:473-91. Effects of trichloroethylene on visual-motor performance. 16. Drinking water contaminants and adverse pregnancy outcomes: a Review. 2009. Reif JS, Burch JB, Nuckols JR, Metzgar L, et al. INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the contamination of drinking water. Environ Health Perspect 110(S): 61-73. Trichloroethylene is primarily used as a solvent to remove greases from metal parts. 17. Cooper GS, Makris SL, Nietert PJ, Jinot J. 1999. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries — persons with documented exposure to TCE through drinking and use of contaminated … The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Trichloroethylene has a long list of potentially hazardous health effects. Until our knowledge will permit the acknowledgment of such dose, all we can do to protect human health is to consider that the presence of TCE may be harmful in any amount and our goal shoul… Neurological Effects 22. Grosse Y, Baan R, Straif K, Secretan B, et al. Bove F, Shim Y, Zeitz P. 2002. TrichloroethyleneHealth Effects on Respiratory system: It stimulates respiration causing tachypnoea. hތ��n��_e.e��� $Ӳ�N *Q��\�ɵL�"rXo����YYT���{�P]]�����Ln�u�M%N>穤)�:�5mۣgp�����ScK�7W�rv���~��tw�n�����wO�����������w���8��~����W�{������x}�����������㓧Ww?��]|x����Nӓ�=O.��}ʻo_�_�S6vw��߿8\���8�w燱��������Ô�>Ϟ��6]|���ǖ��b����o>>������~���>L����\ċ�_�”����O�w�ݳo~x��oc��=���x8^��I��7������qs}�����ar����ݿ�^��X�=����w�^���ų�Á%~�� �/o��bLN/�_�}�������&�������H��-~>�� ��'wof7��T�%NI�R�e/m.EF��B_��|�e�N-L�籩�ц��>�f�e��ٸ�P�i�Ӝ��f���.B�K=RQ,��Tc���^N5�V���Tk���h9&k�����I�E3ȥD��d��1km�sS�I4�G. 1. 1995. 2003. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. 9. Effects to the liver, kidneys, and immune and endocrine systems have also been seen in humans exposed to trichloroethylene occupationally or from contaminanted drinking water. Additionally, listed below are other health effects that have been linked to TCE, PCE, benzene, and/or vinyl chloride in populations other than Camp Lejeune who worked with and/or drank water contaminated with these chemicals. Also, in assessing the entry, exposure, and effects of trichloroethylene on the environment, several data gaps have been identified. Environ Health Perspect 121:303-311. 2003. Paulu C, Aschengrau A, Ozonoff D. 1999. 13. Massachusetts Department of Public Health, Centers for Disease Control and Prevention, Massachusetts Health Research Institute. Feldman RG, Chirico-Post J, Proctor SP. Author information: (1)Exposure and Disease Registry Branch, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia 30333, USA. Liver, kidney, immunological, endocrine, and developmental effects have also been reported in humans. These links are based on studies with positive associations between exposures to these chemicals and development of health effects. 7. Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. Trichloroethylene: health effects, incident management and toxicology Information on trichloroethylene (also known as trichloroethene), for use in responding to chemical incidents. 2007. Trichloroethylene; CASRN 79-01-6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . Evidence of Autoimmune-Related Effects of Trichloroethylene Exposure from Studies in Mice and Humans. This document combined the findings from ATSDR’s Camp Lejeune studies with findings from studies of other populations exposed occupationally or environmentally to TCE, PCE, vinyl chloride and benzene. Public drinking water contamination and birth outcomes. Chonal atresia (nasal passages blocked with bone or tissue) (1, 2), Oral cleft defects (including cleft lip) (, Neurological effects (delayed reaction times problems with short-term memory, visual perception, attention, and color vision) (, Neurobehavioral performance deficits (i.e., delayed recall and deficits in visual perception), decreased blink reflex, and mood effects (i.e., confusion, depression and tension) (, Severe, generalized hypersensitivity skin disorder (an autoimmune-related disease) (. Long Term Effects: Exposure to trichloroethylene in the workplace may cause scleroderma (a systemic autoimmune disease) in some people. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons with documented exposure to TCE through drinking and use of contaminated water. Exposure to TCE raises a number of health effects concerns, including for effects in the developing fetus from both acute and chronic exposure. Sacramento, California. Toxicol Appl Pharmacol 42:417-423. Short Review: Benzene’s toxicity: a consolidated short review of human and animal studies. Am J Epidemiol 141:850-62. Bove FJ, Fulcomer MC, Klotz JB, Esmart J, et al. Trichloroethylene (TCE) is a man-made chemical that can be a liquid or gas. Human health effects of trichloroethylene: key findings and scientific issues. Can cause dry, red, cracked skin (dermatitis) following skin contact. Public health goal for trichloroethylene in drinking water. High acute concentrations of TCE vapors can irritate the respiratory system and skin and induce central nervous system effects such as light-headedness, drowsiness, and headaches. March 31, 1987 TRICHLOROETHYLENE Health Advisory Office of Drinking Water U.S. Environmental Protection Agency I. 3. 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